This may help. I have a REL Storm III and two HSU MBM-12's with the full RF-7 home theater/music set minus the RSW-15 (nice but not available when I purchased).
Tuning is really a science and an art. I have a 10K SF listening room. My mains are set to full. The center and surrounds are set to small. My REL is connected to the leads off the mains and set to full range, but at only approximately 1/3 volume. The MBM 12's are connected to the LFE and set to full range at approximately 2/3 volume.
When I ran my Yamaha recievers' "room calibration" feature using the recievers' microphone (this compensates for various room dimensions by adjusting output to each speakers frequencies and volumes separately to produce a flat responce all around), I had the REL and MBM's turned off. I tuned them by ear after I was happy with the reciever's calibration of the Klipsches. This balance has worked best to my ears for both music and cinema.
Often, the recommendation is having the sub blend with the specs on your mains. If they play down to 34 Hz, set your sub up to play at 34 +/- Hz and below.
Many like setting mains to "small" in the reciever/processor, and setting the mains crossover in the reciever to a higher crossover point than their natural 34 Hz such as the THX 80 Hz, and adjusting the sub to cover the entire range from 80 Hz and below.
For my ears, all three techniques can sound very good because I tried each. My way is just my personal preference. I like the fuller range at lower volumes, and when adjusting the volume up, it simply gets better. The room calibrator in the reciever gets honorable mention.
The listening area is much larger than the calibration microphone. Moving the smaller mike just 1-3 feet around (up, down, side-to-side) within the larger listening area (money seats) can make a significant calibration change.
It took 3-4 runs to get the Klipshes calibrated correctly. Then, I tuned in the MBM's and REL by ear. Subwoofer waves seem to be very mysterious - seemingly more so than mid-bass modules. Placement can be huge. The REL is next to my RF-7's, and the MBM's are flanking my couch. They sound good flanking thecenter speaker, too. The MBM ports can be aimed directly into the key seating area for home theater. Hope something here helps.