Thanks for all of the input.
I wanted to give you all a better lay of the room so you know what I am facing. Maybe that will result in different recommendations.
First, room is 24 x 16 with cathedral ceiling (peak at 13 ft) dividing the length. HT unit is on wall opposite couch on the 16 ft span placing us approximately 10 ft away for viewing. Couch sits against the 11 ft stretch of wall between two openings. On one side of couch is door to hallway, followed by a 6 foot span of wall to corner of room. On other side of couch is door to kitchen/dining which is on about 4 inches from other corner, turning with a window about 12 inches down. Again, ceiling peaks at 13 ft about two foot into wall off door from hallway (almost over the end of the couch).
If I place speakers on rear wall, they would be over the 11 foot piece behind couch and end tables. Was thinking bottom of speaker would be almost even with top of door jam on each side, which would be right at 7 foot. They would be about 9 ft apart.
If I placed them on sides of room, one would be approx 11 ft from couch, and the other only about 5 ft, but between opening to kitchen/dining and window. They would also need to be mounted almost against ceiling (lowest point on each side) with top of speaker at about 7 ft and 4 inches.
Not sure if these speakers (on wall being the RS52) or in wall (R5650-S) allow you to point/position horns. I do know that the RS52 speakers are fairly large (13x12.5x8.5 deep) and would look best mounted flush against the wall.
Does this description change anyone's opinion or give way to any other ideas?