Assuming you're referring to the EV T-35/K-77 tweeter, it's my understanding that the dispersion is marginally better with the long dimension oriented vertically. PWK is said to have oriented the tweeter with the long dimension in the horizontal plane for reasons of manufacturing simplicity and economics; not for sonic superiority.
I would place the tweeters in the vertical orientation with one on the left of the squawker horn in one speaker and in mirror image on the other speaker. That way, you could experiment to decide if you prefer having the tweeters on the inside or the outside of the squawker horns.